Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 tetrameric complex
Resolution: 7.86 Å
EM Method: Single-particle
Fitted PDBs: 8h33
Q-score: 0.07
Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L
Nat Struct Mol Biol (2024) 31 pp. 336-350 [ Pubmed: 38332366 DOI: doi:10.1038/s41594-023-01182-6 ]
- Kbtbd2-cul3-rbx1 tetrameric complex (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Kelch repeat and btb domain-containing protein 2 (71 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (13 kDa, Protein from Homo sapiens)
- Cullin-3 (90 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 hexameric complex
Resolution: 7.99 Å
EM Method: Single-particle
Fitted PDBs: 8h34
Q-score: 0.088
Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L
Nat Struct Mol Biol (2024) 31 pp. 336-350 [ Pubmed: 38332366 DOI: doi:10.1038/s41594-023-01182-6 ]
- Zinc ion (65 Da, Ligand)
- Kelch repeat and btb domain-containing protein 2 (71 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (13 kDa, Protein from Homo sapiens)
- Kbtbd2-cul3-rbx1 hexameric complex (Complex from Homo sapiens)
- Cullin-3 (89 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 octameric complex
Resolution: 7.41 Å
EM Method: Single-particle
Fitted PDBs: 8h35
Q-score: 0.091
Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L
Nat Struct Mol Biol (2024) 31 pp. 336-350 [ Pubmed: 38332366 DOI: doi:10.1038/s41594-023-01182-6 ]
- Kbtbd2-cul3-rbx1 octameric complex (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Kelch repeat and btb domain-containing protein 2 (71 kDa, Protein from Homo sapiens)
- Cullin-3 (89 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a dimeric complex
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 8h36
Q-score: 0.068
Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L
Nat Struct Mol Biol (2024) 31 pp. 336-350 [ Pubmed: 38332366 DOI: doi:10.1038/s41594-023-01182-6 ]
- Kbtbd2-cul3-rbx1-p85a dimeric complex (Complex from Homo sapiens)
- Kelch repeat and btb domain-containing protein 2 (71 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- Cullin-3 (89 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a tetrameric complex
Resolution: 7.52 Å
EM Method: Single-particle
Fitted PDBs: 8h37
Q-score: 0.057
Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L
Nat Struct Mol Biol (2024) 31 pp. 336-350 [ Pubmed: 38332366 DOI: doi:10.1038/s41594-023-01182-6 ]
- Kelch repeat and btb domain-containing protein 2 (71 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- Cullin-3 (89 kDa, Protein from Homo sapiens)
- Kbtbd2-cul3-rbx1-p85a tetrameric complex (Complex from Homo sapiens)
Cryo-EM Structure of the KBTBD2-CRL3~N8-CSN(mutate) complex
Resolution: 4.25 Å
EM Method: Single-particle
Fitted PDBs: 8h38
Q-score: 0.078
Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L
Nat Struct Mol Biol (2024) 31 pp. 336-350 [ Pubmed: 38332366 DOI: doi:10.1038/s41594-023-01182-6 ]
- Cop9 signalosome complex subunit 6 (36 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (47 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)
- Kbtbd2-crl3~n8 dimer assemble with csn(mutate) monomer (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Csn (Complex)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Csn subunit1, kbtbd2, cullin-3, rbx1 (Complex)
- Kelch repeat and btb domain-containing protein 2 (71 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (59 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (37 kDa, Protein from Homo sapiens)
- Cullin-3 (89 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Nedd8 (Complex)
- Cop9 signalosome complex subunit 7b (29 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the KBTBD2-CRL3~N8(removed)-CSN complex
Resolution: 7.51 Å
EM Method: Single-particle
Fitted PDBs: 8h3a
Q-score: -0.024
Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L
Nat Struct Mol Biol (2024) 31 pp. 336-350 [ Pubmed: 38332366 DOI: doi:10.1038/s41594-023-01182-6 ]
- Cop9 signalosome complex subunit 6 (36 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (47 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (37 kDa, Protein from Homo sapiens)
- Kelch repeat and btb domain-containing protein 2 (71 kDa, Protein from Homo sapiens)
- Cryo-em structure of the kbtbd2-crl3~n8-csn complex (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Csn (Complex)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (59 kDa, Protein from Homo sapiens)
- Cullin-3 (89 kDa, Protein from Homo sapiens)
- Kbtbd2, cullin-3, rbx1 (Complex)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 7b (29 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the KBTBD2-CRL3-CSN complex
Resolution: 6.73 Å
EM Method: Single-particle
Fitted PDBs: 8h3f
Q-score: -0.046
Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L
Nat Struct Mol Biol (2024) 31 pp. 336-350 [ Pubmed: 38332366 DOI: doi:10.1038/s41594-023-01182-6 ]
- Cop9 signalosome complex subunit 6 (36 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (37 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Csn (Complex)
- Kelch repeat and btb domain-containing protein 2 (73 kDa, Protein from Homo sapiens)
- Cryo-em structure of the kbtbd2-crl3-csn complex (Complex from Homo sapiens)
- Cop9 signalosome complex subunit 7b (24 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (59 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (49 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (13 kDa, Protein from Homo sapiens)
- Cullin-3 (89 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Kbtbd2-crl3 (Complex)
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the CAND1-Cul3-Rbx1 complex
Resolution: 3.76 Å
EM Method: Single-particle
Fitted PDBs: 8h3q
Q-score: 0.239
Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L
Nat Struct Mol Biol (2024) 31 pp. 336-350 [ Pubmed: 38332366 DOI: doi:10.1038/s41594-023-01182-6 ]
- Cand1-cul3-rbx1 complex (Complex from Homo sapiens)
- Cul3, rbx1 (Complex)
- Zinc ion (65 Da, Ligand)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Cullin-associated nedd8-dissociated protein 1 (136 kDa, Protein from Homo sapiens)
- Cullin-3 (89 kDa, Protein from Homo sapiens)
- Cand1 (Complex)
Cryo-EM Structure of the KBTBD2-CRL3~N8 dimeric complex
Resolution: 6.36 Å
EM Method: Single-particle
Fitted PDBs: 8h3r
Q-score: 0.04
Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L
Nat Struct Mol Biol (2024) 31 pp. 336-350 [ Pubmed: 38332366 DOI: doi:10.1038/s41594-023-01182-6 ]
- Zinc ion (65 Da, Ligand)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Kelch repeat and btb domain-containing protein 2 (71 kDa, Protein from Homo sapiens)
- Cullin-3 (89 kDa, Protein from Homo sapiens)
- Kbtbd2-crl3~n8 dimeric complex (Complex from Homo sapiens)